Table 3. Multivariable Cox regression model analysis of RFS and OS.

Independent predictive factor	HR	95% CI	P value
RFS (before PSM)
Anesthesia methods
LA	1
GA	1.314	1.021–1.691	0.034
TNM stage
I	1
II	2.924	1.558–5.487	0.001
Tumor size
<3 cm	1
≥3 cm	1.356	1.043–1.762	0.023
Adjuvant chemoradiotherapy
No	1
Yes	1.531	1.163–2.016	0.002
Cirrhosis
No	1
Yes	1.428	1.027–1.985	0.034
Hypertension
No	1
Yes	1.238	0.927–1.652	0.149
ASA score
II	1
III	1.295	0.935–1.792	0.12
Age
≤60	1
>60	1.162	0.901–1.497	0.247
Tumor number
Solitary	1
Multiple	1.363	0.981–1.894	0.065
Diabetes
No	1
Yes	1.125	0.790–1.601	0.515
RFS (after PSM)
Anesthesia methods
LA	1
GA	1.593	1.193–2.127	0.002
TNM stage
I	1
II	2.72	1.099–6.728	0.03
Tumor size
<3 cm	1
≥3 cm	1.513	1.119–2.045	0.007
Adjuvant chemoradiotherapy
No	1
Yes	1.838	1.308–2.581	0
Cirrhosis
No	1
Yes	1.59	1.073–2.357	0.021
ASA score
II	1
III	1.533	1.085–2.165	0.015
ALB
>35 g/L	1
≤35 g/L	1.458	1.018–2.089	0.04
Tumor number
Solitary	1
Multiple	1.484	0.588–3.745	0.404
OS (before PSM)
Anesthesia methods
LA	1
GA	1.357	0.865–2.128	0.184
TNM stage
I	1
II	1.744	1.051–2.897	0.032
Tumor size
<3 cm	1
≥3 cm	1.64	1.016–2.647	0.043
ALB
>35 g/L	1
≤35 g/L	1.483	0.810–2.713	0.201
Child-Pugh stage
A	1
B	1.221	0.572–2.607	0.605
Cirrhosis
No	1
Yes	1.75	0.896–3.420	0.101
OS (after PSM)
Anesthesia methods
LA	1
GA	1.746	1.036–2.943	0.036
TNM stage
I	1
II	1.965	1.078–3.583	0.028
Tumor size
<3 cm	1
≥3 cm	1.847	1.064–3.205	0.029
ALB
>35 g/L	1
≤35 g/L	1.913	0.964–3.798	0.064
Child-Pugh stage
A	1
B	1.672	0.723–3.868	0.23

RFS, recurrence-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; TNM, Clinicopathological stage; ASA, American Society of Anesthesiologists; ALB, serum albumin; LA, local anesthesia; GA, general anesthesia; PSM, propensity score matching.