Table 3. IHC results of CPGJ701 binding to tissues in normal humans, cynomolgus monkeys and Sprague-Dawley rats.
| 32 tissues | Bio-CPGJ701 (50 μg/mL) | ||
|---|---|---|---|
| Humans | Cynomolgus monkeys | Sprague-Dawley rats | |
| Breast cancer | 1+ (3/3) | / | / |
| Heart | 1+ (2/3) | 1+ (2/3), ± (1/3) | 1+ (1/3), ± (2/3) |
| Lung | 1+ (2/3) | – | 1+ (1/3), ± (1/3) |
| Liver | 1+ (2/3) | 1+ (3/3) | ± (1/3) |
| Spleen | – | – | – |
| Kidney | 2+ (2/3), ± (1/3) | 1+ (2/3), ± (1/3) | 1+ (3/3) |
| Ureter | 2+ (1/3) | 1+ (2/3), 2+ (1/3) | 1+ (2/3), ± (1/3) |
| Stomach | 1+ (2/3), 2+ (1/3) | 1+ (1/3), 2+ (2/3) | 1+ (3/3) |
| Pituitary | 1+ (2/3), 2+ (1/3) | 1+ (2/3), ± (1/3) | 1+ (2/3), ± (1/3) |
| Adrenal | 1+ (2/3), 2+ (1/3) | 1+ (3/3) | – |
| Thyroid | 1+ (2/3), ± (1/3) | 1+ (1/3) | – |
| Parathyroid | ND | 1+ (2/3), 2+ (1/3) | 1+ (3/3) |
| Bladder | 1+ (2/3), 2+ (1/3) | 1+ (2/3), 2+ (1/3) | 1+ (2/3), ± (1/3) |
| Cerebellum | 1+ (1/3), ± (2/3) | 1+(1/3), ± (1/3) | 1+ (2/3), ± (1/3) |
| Cerebral cortex | 1+ (2/3), ± (1/3) | 1+ (1/3) | 1+ (2/3), ± (1/3) |
| Colon | – | ± (1/3) | ± (2/3) |
| Retina | 1+ (1/1) | 1+ (2/3) | 1+ (2/3) |
| Lymph node | – | – | – |
| Breast | 1+ (3/3) | 1+ (2/3), 2+ (1/3) | 1+ (1/3) |
| Pancreas | 1+ (1/3) | 1+ (2/3), ± (1/3) | 1+ (3/3) |
| Prostate | 1+ (2/3) | ± (1/3) | ± (1/3) |
| Skin | 1+ (1/3), 2+ (1/3), ± (1/3) | 1+ (2/3), ± (1/3) | – |
| Striated muscle | – | – | ± (1/3) |
| Testes | 1+ (2/3), 2+ (1/3) | 1+ (3/3) | 1+ (2/3) |
| Thymus | – | – | – |
| Uterus | 1+ (1/3), 2+ (1/3) | 1+ (1/3) | 1+ (3/3) |
| Ovaries | – | 1+ (1/3) | – |
| Fallopian tube | 1+ (2/3) | 1+ (2/3), ± (1/3) | – |
| Bone marrow | – | – | – |
| Placenta | ± (1/3) | – | 1+ (2/3), ± (1/3) |
| Endothelium | – | – | – |
| Blood cells | – | – | – |
| Spinal cord | 1+ (1/3), ± (2/3) | 1+ (3/3) | – |
– indicates negative; ± indicates weak staining; 1+ indicates mild staining; 2+ indicates moderate staining; 3+ indicates strong staining; ND indicates not done; / indicates no; (/) indicates the proportion of different grades of staining. IHC, immunohistochemistry.