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The diagram of transition between EMT and MET. (A) At the specific conditions, the switch between EMT and MET will occur; (B) activated RPE cell (by inflammatory factors) release HGF and HGF induces the disconnection of individual RPE from the monolayer to dedifferentiated RPE through a transmembrane tyrosine kinase receptor (HGF receptor). EMT, epithelial-mesenchymal transition; MET, mesenchymal-epithelial transition.
