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. 2020 Mar;8(6):318. doi: 10.21037/atm.2020.02.143

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Schematic representation of the murine Dnmt3a locus. (A) Natural variants of DNMT3A in AML. (B) Schematic representation of the Dnmt3a R878H mouse model. (C) Diagram of the breeding of Dnmt3a^R878H/WTMx1-Cre⁺ mice.