Figure 6.

TCGA PAAD patients’ immune cell fractions were altered by seven targeted DEmRNAs. (A) TCGA PAAD patients’ immune infiltration status was analyzed by CIBERSORT using RNA-seq data; (B) some immune cell types showed high correlation with others. T cells CD4⁺ memory activated showed positive correlation with T cells CD8, whereas T cells CD4⁺ memory resting negatively correlated with macrophages M0, T cells follicular helper, B cells naïve, and T cells regulatory, indicating totally different roles of resting and activating CD4⁺ memory T cells; (C-I) regrouping PAAD dataset by level of seven DEmRNAs expression, the fraction of CD4⁺ memory T cells significantly changed. T cells CD4⁺ memory resting was significantly altered by MSI2, TEAD1, GNPDA1, PRKACB, TRIM68, and YKT6, whereas T cells CD4⁺ memory activated were significantly altered by RND3; (J) alteration of infiltrating immune cells through seven DEmRNAs targeted by hsa-miR-485-3p, hsa-miR-574-5p, and hsa-miR-584-5p.