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. 2020 Mar;8(6):279. doi: 10.21037/atm.2020.03.53

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Schematic illustration of a CD4⁺ memory T cell immune-related miRNAa regulatory network associated with PC gemcitabine resistance. In gemcitabine-resistant pancreatic cancer cells, hsa-miR-485-3p, hsa-miR-574-5p, and hsa-miR-584-5p were up-regulated, served as activators of gene expression according to miRNAa hypothesis, promoted the expression of seven targeted mRNAs, including MSI2, TEAD1, GNPDA1, RND3, PRKACB, TRIM68, and YKT6. Complicatedly, MSI2, TEAD1, GNPDA1, RND3, PRKACB, and TRIM68 increased the fractions of CD4⁺ memory T cells, while YKT6 suppressed them.