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. 2020 Mar;8(6):302. doi: 10.21037/atm.2020.03.31

Figure 4.

Figure 4

Chemical inhibition of SLC1A5 or GPT2 synergistically enhanced the treatment effect of chemotherapy in SRCC. (A) V-9302 (20 µM) administration significantly inhibited SRCC organoids growth but did not impact the organoids with SLC1A5 depletion; (B) AOA (10 mM) administration significantly inhibited SRCC organoids growth but did not impact the organoids with GPT2 depletion; (C) qRT-PCR showing V-9302 or AOA administration strikingly reduced expression of CD44 and LGR5; (D) apoptosis analysis of SRCC organoids treated with single 5-fu (1 mM) or L-OHP (20 µM) and inhibitors (V-9302 and AOA). *, P<0.05. SRCC, signet-ring cell carcinoma.