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. 2020 Mar;8(6):350. doi: 10.21037/atm.2020.02.103

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2020 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Ipsilateral and contralateral knees developed OA in distinct patterns in murine ACLT model. (A) Representative photos of Safranin O and fast green staining of ipsilateral (upper) an contralateral side of knee joints 0, 1, 3 and 6 months after ACLT; (B) statistical analysis, n=8 per group, statistical significance was determined by unpaired Student’s t test and all data were shown as a bar with means ± standard deviations. Scale bars, 500 µm. **, P<0.01, ***, P<0.001 compared with the sham operated group at different time points. ACLT, anterior cruciate ligament transection; OA, osteoarthritis.