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. 2020 Apr 28;30(6):541–543. doi: 10.1038/s41422-020-0318-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Electron microscopic examination on a single pulmonary bronchiolar epithelial cell. Black arrows in left panel indicate organelle in pulmonary epithelial cell. Red arrows in right panel label virus particles. Scale bar: 1 μm in left panel and 200 nm in right panel. b Electron microscopic examination on a single type II alveolar epithelial cell. Yellow arrow indicates organelle in pulmonary epithelial cell. Red arrows label virus particles. Scale bar: 200 nm. c Immunohistochemical (IHC) staining of SARS-CoV-2 nucleoprotein (N) in pulmonary tissue with monoclonal anti-nucleoprotein antibody. The inset represents magnification of the selected area. Dark brown signals indicate positive staining for SARS-CoV-2 nucleoprotein and nuclei are counterstained with hematoxylin. Scale bar: 50 μm. d H&E staining shows desquamated and enlarged epithelial cells. Scale bar: 50 μm. e H&E staining shows exudative monocytes/macrophages in alveoli. Red arrows show typical macrophages in alveoli. Scale bar: 50 μm. f H&E staining shows formation of hyaline membranes. Scale bar: 50 μm. g IHC staining indicates lung-infiltrated immune cells: CD68⁺ macrophages, CD20⁺ B cells, and CD8⁺ T cells. Scale bar: 50 μm.