Table 2.
Biological activity of urea derivatives 16, 23‐25 and 27 compared to cystobactamid 861–2 (5) (MIC values in μg mL−1; nd=not determined).[a]
|
Strain |
16 |
23 |
24 |
25 |
27 |
5 |
|---|---|---|---|---|---|---|
|
S. aureus Newman |
16 |
>64 |
>64 |
>64 |
>64 |
1 |
|
E. coli BW25113 |
≤0.03 |
nd |
1 |
nd |
>64 |
0.25 |
|
E. coli ΔacrB |
≤0.03 |
nd |
≤0.03 |
nd |
>64 |
≤0.003 |
|
E. coli ΔtolC |
nd |
>64 |
nd |
>64 |
nd |
≤0.003 |
|
E. coli DSM‐1116 |
nd |
>64 |
nd |
>64 |
nd |
0.2 |
|
P. aeruginosa PA14 |
1 |
>64 |
>64 |
>64 |
>64 |
1 |
|
PA14ΔmexAB |
1 |
>64 |
>64 |
>64 |
>64 |
0.25 |
[a] Values for ciprofloxacin (CP) are listed in Table 3.