Table 4. . Adverse events for the entire subject cohort.

Adverse events	Total (n = 106)
	All grades	Grade 3/4
Total	96 (90.6%)	3 (2.8%)
Fatigue/weakness	58 (54.7%)	1 (0.9%)
Diarrhea/colitis	16 (15.1%)	0 (0%)
Hypophysitis	0 (0%)	0 (0%)
Thyroid	11 (10.4%)	0 (0%)
Adrenal insufficiency	1 (0.9%)	0 (0%)
Pneumonitis	6 (5.7%)	2 (1.8%)
Rash/pruritis	17 (16.0%)	0 (0%)
Liver	2 (1.8%)	0 (0%)
Nephropathy	9 (8.5%)	0 (0%)
Dyspnea	23 (21.7%)	0 (0%)
Edema	11 (10.4%)	0 (0%)
Constipation	9 (8.5%)	0 (0%)
Nausea/vomiting	14 (13.2%)	0 (0%)
A fib	1 (0.9%)	0 (0%)
Arthralgia/myalgia	10 (9.4%)	0 (0%)
Pneumonia/upper respiratory infection	12 (11.3%)	0 (0%)
Flu like symptoms	2 (1.8%)	0 (0%)
Hypersensitivity reaction	1 (0.9%)	0 (0%)
Other	10 (9.4%)	0 (0%)
Discontinued due to adverse event	20 (18.9%)