Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 23;15:2841–2858. doi: 10.2147/IJN.S239608

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Kong et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Cellular uptake and distribution after incubation with varying formulations. (A) Cellular uptake of hCMEC/D3 cells treated with RhB liposomes and Tf-modified RhB liposomes; (B) Quantitative analysis of fluorescence intensity; Data are presented as mean ± SD (n=3). a, vs Blank control; b, vs RhB liposomes. P<0.05; (C) Cellular uptake of hCMEC/D3 cells treated with Tf-modified RhB liposomes at different time points; (D) Quantitative analysis of fluorescence intensity; Data are presented as mean ± SD (n=3). *, vs 1 h; #, vs 2 h. P<0.05. (E) Analysis of fluorescence intensity of hCMEC/D3 cells incubated with the varying liposomal formulations by fluorescence microscopy, scale bar=100 μm (n=3). (F) Cellular uptake of SH-SY5Y incubated with the varying liposomal formulations by fluorescence microscopy in a co-culture model, scale bar=50 μm (n=3). (G) The ratio of Ost transported across the BBB in vitro (n=3). *, vs Ost-Lip. P<0.05.