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. 2020 Apr 23;15:2841–2858. doi: 10.2147/IJN.S239608

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© 2020 Kong et al.

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The therapeutic effects of the varying formulations on the cognitive decline of APP/PS-1 mice. (A)-(F) The learning ability of different groups of mice was determined by MWM. (A) The representative swimming paths in the water maze trial on day 5. (B) Escape latency of the water maze task. (C) Swimming distance in the formal experimentals of the water maze task. Data are presented as mean ± SD (n=6). a, vs APP; b, vs Ost; c, vs Ost-Lip. P<0.05. (D) Times of crossing the removed-platform. (E) The time spent of mice in the target quadrant. (F) Swimming speed of mice. Data are presented as mean ± SD (n=6). *P<0.05, **P<0.01. (G–H) Effects of the varying formulations on nest building behavior in APP/PS-1 mice. (G) Representative images were obtained from 0 to 3 days. (H) Analysis of nesting score in APP/PS-1 mice after treatment with the varying formulations. Data are presented as mean ± SD (n=6). *P<0.05, **P<0.01.