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Pharmacokinetic Parameters of Ost Following Intravenous Administration of the Varying Formulations in SD Rats at 10 Mg/Kg Ost Dose (n = 6)
| Parameters | Free Ost | Ost-Lip | Tf-Ost-Lip |
|---|---|---|---|
| t1/2α (h) | 0.172±0.237 | 0.216±0.314 | 0.200±0.250 |
| t1/2β (h) | 0.602±0.303 | 3.673±2.281 | 3.382±1.239 |
| V1 (L/kg) | 67.501±16.848 | 13.702±6.556 | 14.891±9.106 |
| CL (L/h/g) | 154.769±30.508 | 8.461±1.937 | 8.326±2.348 |
| AUC0–48 h (mg/L/h) | 0.119±0.027 | 2.379±0.577 | 2.488±0.861 |
