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Pharmacokinetic Parameters of Ost in Brain After Administration of Varying Formulations (n = 6)
| Formulation | AUC0–24 h (μg/g/h) | Cmax (μg/g) | tmax (h) | MRT (h) | Re | Ce |
|---|---|---|---|---|---|---|
| Free Ost | 344.82±67.16 | 0.71±0.17 | 2 | 6.39±0.51 | — | — |
| Ost-Lip | 489.19±60.31 | 0.75±0.11 | 2 | 7.85±0.08 | 1.39 | 1.25 |
| Tf-Ost-Lip | 791.63±72.89 | 1.46±0.38 | 2 | 7.33±0.38 | 3.74 | 3.38 |
