Table 1. Demographic Characteristics of A16 Original Eligible Cohort, Primary Cohort, Test Cases, and Supplemental Autopsy Cases.
| Variable | Mean (SD) | |||
|---|---|---|---|---|
| Normal cognition | Mild cognitive impairment | Dementia | Total | |
| Original eligible cohort | ||||
| No. | 50 | 3 | 103 | 156 |
| Age, y | 75.2 (15.1) | 82.0 (10.4) | 82.5 (10.5) | 80.2 (12.5) |
| Female sex, No. (%) | 23 (46) | 1 (33) | 62 (60) | 86 (55) |
| White race/ethnicity, No. (%) | 42 (84) | 3 (100) | 98 (95) | 143 (92) |
| Educational level, y | 14.4 (3.16) | 11.3 (5.03) | 14.9 (3.25) | 14.7 (3.27) |
| MMSE scorea | 27.3 (3.44) | 23 (2.65) | 11.8 (9.47) | 21.3 (9.83) |
| IQCODE scorea | 3.2 (0.53) | 3.5 (0.40) | 4.8 (0.39) | 4.5 (0.78) |
| Primary cohort | ||||
| No. (%) | 14 (22) | 1 (2) | 49 (77) | 64 (100) |
| Age, y | 78.6 (12.1) | 76 | 83.8 (8.6) | 82.5 (9.6) |
| Female sex, No. (%) | 6 (43) | 0 | 28 (57) | 34 (53) |
| White race/ethnicity, No. (%) | 14 (100) | 1 (100) | 47 (96) | 62 (97) |
| Educational level, y | 14.9 (2.91) | 16 | 15.1 (3.53) | 15.0 (3.36) |
| MMSE scoreb | 26.2 (4.21) | 26 | 6.9 (6.86) | 18 (11.07) |
| IQCODE scoreb | 3 (0.60) | 3.4 | 4.9 (0.31) | 4.5 (0.83) |
| Test cases | ||||
| No. | 0 | 0 | 3 | 3 |
| Age, y | NA | NA | 84.0 (5.2) | 84.0 (5.2) |
| Female sex, No. (%) | NA | NA | 1 (33) | 1 (33) |
| White race/ethnicity, No. (%) | NA | NA | 3 (100) | 3 (100) |
| Educational level, y | NA | NA | 16.0 (4.00) | 16.0 (4.00) |
| MMSE scorec | NA | NA | 20 | 20 |
| IQCODE scorec | NA | NA | 4.9 (0.14) | 4.9 (0.14) |
| Supplemental autopsy cases | ||||
| No. | 4 | 3 | 9 | 16 |
| Age, y | 86.8 (12.7) | 72.3 (8.9) | 75.4 (9.9) | 77.7 (11.2) |
| Female sex, No. (%) | 2 (50) | 0 | 4 (44) | 6 (38) |
| White race/ethnicity, No. (%) | 4 (100) | 3 (100) | 9 (100) | 16 (100) |
| Educational level, y | 15.3 (4.57) | 16 (0) | 15.1 (3.33) | 15.3 (3.20) |
Abbreviations: IQCODE, Informant Questionnaire on Cognitive Decline in the Elderly; MMSE, Mini-Mental State Examination; NA, not applicable.
a
MMSE sample size = 85; IQCODE sample size = 132.
b
MMSE sample size = 26; IQCODE sample size = 59.
c
MMSE sample size = 1; IQCODE sample size = 3.