Figure 3.

Association of cerebrospinal fluid chitotriosidase (CHIT1) at diagnosis with primary outcome disease activity parameters at follow‐up. (A) Linear regression analysis for CHIT1 (pg/ml) at diagnostic lumbar puncture (LP) versus median lesion magnetization transfer ratio (MTR; untransformed data, P Shapiro–Wilk = 0.03) at a median 3 years (interquartile range [IQR] = 2–5) later including age at magnetic resonance imaging as covariate; gray shading shows the 95% confidence bands. (B) CHIT1 (pg/ml) at diagnostic LP between groups of fast (Age‐Related Multiple Sclerosis Severity Score [ARMSS] ≥ 5) and slow (ARMSS <5) disability progression as measured at a median 5 years (IQR = 2–7) later. Probability value is derived from a logistic regression including known covariates for disability (sex, age at onset, and disease course); horizontal lines indicate mean and error bars. (C) Receiver operating characteristic curves based on CHIT1 alone or CHIT1 including covariates for discrimination of disability progression as defined in (B). The logarithmic (base 10) transformation was applied for CHIT1.