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. 2020 Feb 3;22(5):743–754. doi: 10.1111/dom.13963

Table 1.

Current second‐generation rapid‐acting insulin analogues in development

Drug Company Core insulin structure Added excipients Mechanism of action
Faster aspart27 Novo Nordisk, Bagsværd, Denmark Insulin aspart Niacinamide (vitamin B3), l‐arginine Increased subcutaneous blood flow
Ultra‐rapid lispro28, 29 Eli Lilly, Indianapolis, IN Insulin lispro Treprostinil, citrate Enhanced vascular permeability and increased local vasodilation
BioChaperone Lispro30 Adocia, Lyon, France Insulin lispro BioChaperone BC222,a citrate Enhanced diffusion
a

An oligosaccharide modified with natural molecules.