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Co‐crystal structure of RORγt with compound 13 (PDB code: 6TLM). (A) The tertiary structure. The final 2Fo−Fc electron density map around compound 13 is shown as an isomesh contoured at 1σ; (B) Close‐up of the allosteric pocket. The polar interactions between RORγt and compound 13 are shown as a grey dotted line. (C) Overlay of the crystal structure of RORγt bound to compound 13 (blue) and RORγt bound to MRL‐871 (green; PDB: 5C4O).
