| Methods |
RCT assessing the effects of the routine administration of an angiotensin‐ converting enzyme inhibitor‐diuretic combination on serious vascular events in patients with diabetes, irrespective of initial blood pressure levels or the use of other blood pressure lowering drugs. |
| Data |
11,140 were randomised (5569/5571, respectively to perindopril‐indapamide and to placebo). |
| Comparisons |
Onsite assessment (local investigator blinded) versus assessment by an AC blinded to allocated treatment. |
| Outcomes |
The outcome selected was a composite outcome of major macro (non fatal myocardial infarction, non fatal stroke and cardiovascular death) and microvascular events (new or worsening nephropathy and retinopathy). This was the study's primary outcome. |
| Notes |
|
| Risk of bias |
| Item |
Authors' judgement |
Description |
| Method for selecting cases to adjudicate? |
No |
All suspect events adjudicated were identified by onsite assessor who was blinded to allocated treatment. |
