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. 2016 Mar 10;2016(3):MR000043. doi: 10.1002/14651858.MR000043.pub2

PURSUIT 2001.

Methods RCT comparing eptifibatide versus placebo in patients with acute coronary syndromes.
Data 10,948 patients were randomised. Data were presented in detail for the primary comparison groups, those assigned to receive high‐dose eptifibatide or placebo (4722/4739, respectively in each treatment group); 1487 patients were allocated to the low‐dose eptifibatide group.
Comparisons Onsite assessment (local investigator blinded) versus assessment by an AC blinded to allocated treatment.
Outcomes The outcome selected was a composite of death or post‐enrolment myocardial infarction (or reinfarction if patients had a myocardial infarction at enrolment) by 30 days. This was the study's primary outcome.
Notes  
Risk of bias
Item Authors' judgement Description
Method for selecting cases to adjudicate? No All suspect events adjudicated were identified through a computer algorithm.