Table 1.
Hemodynamic and physiological parameters in seven fetal sheep at different time intervals following placement on EXTEND support
| Parameter | Time since placement on EXTEND support | F | P | |||
|---|---|---|---|---|---|---|
| Day 0 | Week 1 | Week 2 | Week 3 | |||
| HR (bpm) | 184 ± 20 | 189 ± 7 | 168 ± 22 | 152 ± 15 | 6.52 | 0.002* |
| MAP (mmHg) | 28.0 ± 8.0 | 32.4 ± 4.5 | 32.7 ± 2.9 | 37.4 ± 5.7 | 3.28 | 0.04† |
| LV‐CO (mL/min/kg) | 215 ± 42 | 218 ± 35 | 213 ± 36 | 212 ± 50 | 0.04 | 0.99 |
| RV‐CO (mL/min/kg) | 309 ± 81 | 310 ± 57 | 301 ± 56 | 299 ± 73 | 0.04 | 0.98 |
| CCO (mL/min/kg) | 524 ± 122 | 528 ± 92 | 514 ± 92 | 511 ± 123 | 0.04 | 0.99 |
| Circuit flow (mL/min/kg) | 208 ± 37 | 247 ± 101 | 213 ± 98 | 193 ± 103 | 0.45 | 0.72 |
| Circuit flow/CCO | 0.41 ± 0.09 | 0.45 ± 0.10 | 0.40 ± 0.11 | 0.36 ± 0.10 | 0.98 | 0.42 |
| UA‐PI | 0.46 ± 0.14 | 0.46 ± 0.09 | 0.41 ± 0.09 | 0.55 ± 0.09 | 2.35 | 0.1 |
| MCA‐PI | 0.83 ± 0.20 | 0.81 ± 0.27 | 0.69 ± 0.19 | 0.76 ± 0.12 | 0.63 | 0.61 |
| DV‐PI | 0.43 ± 0.11 | 0.46 ± 0.19 | 0.41 ± 0.05 | 0.45 ± 0.21 | 0.14 | 0.93 |
Data are given as mean ± SD.
Variables compared between time intervals using repeated‐measures ANOVA with post‐hoc pairwise comparisons performed in case of significant difference.
Post‐hoc comparison showed significant difference compared with 3 weeks at:
*
0 days (P = 0.01) and 1 week (P = 0.004); and
†
0 days (P = 0.03).
CCO, combined cardiac output divided by body weight; CO, cardiac output divided by body weight; DV, ductus venosus; HR, heart rate; LV, left ventricle; MAP, mean arterial pressure proximal to oxygenator; MCA, middle cerebral artery; PI, pulsatility index; RV, right ventricle; UA, umbilical artery.