Table 3.
Determinants of LSM values ≥ 9.9 kPa in patients with WD (univariable and multivariable binary regression analyses)
| Univariable | Multivariable‐Model APRI | Multivariable‐Model FIB‐4 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95%CI | P‐value | OR | 95%CI | P‐value | OR | 95%CI | P‐value | |
| Age | 1.02 | 0.99‐1.04 | .097 | 1.03 | 0.99‐1.06 | .066 | — | — | — |
| Gender (being female) | 0.47 | 0.24‐0.90 | .023 | 0.26 | 0.11‐0.65 | .004 | 0.30 | 0.12‐0.76 | .011 |
| Cirrhosis on LBX | 9.07 | 4.35‐18.92 | <.001 | 9.17 | 3.62‐23.26 | <.001 | 9.70 | 3.87‐24.28 | <.001 |
| AST | 1.00 | 0.99‐1.01 | .106 | — | — | — | — | — | — |
| ALT | 1.00 | 0.99‐1.01 | .209 | — | — | — | — | — | — |
| PLT | 0.98 | 0.97‐0.99 | <.001 | — | — | — | — | — | — |
| APRIa | 3.74 | 2.15‐6.53 | <.001 | 3.25 | 1.71‐6.19 | <.001 | — | — | — |
| FIB‐4a | 2.28 | 1.66‐3.12 | <.001 | — | — | — | 1.83 | 1.30‐2.59 | .001 |
| Treatment >1 y at time of first LSM (OR for being under treatment at first TE) | 0.38 | 0.18‐0.77 | .007 | 0.75 | 0.26‐2.13 | .584 | 0.57 | 0.21‐1.49 | .248 |
Abbreviations: LSM, liver stiffness measurement; TE, transient elastography; WD, Wilson disease.
a
Available in 182 patients.