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. 2019 Nov 27;9(3):307–320. doi: 10.1002/cpdd.749

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© 2019 Pfizer Inc. Clinical Pharmacology in Drug Development published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Observed and predicted (regression line) change from baseline in QTcF versus sertraline (P < .0001) (A) and N‐desmethylsertraline (P < .0001) (B) plasma concentrations on day 14 after administration of sertraline 400 mg/day.^a QTcF, QT corrected for heart rate using Fridericia formula. Open circle represents observed data, solid red line represents regression line, and dotted red line represents 90% confidence interval. ^aDosing was 200 mg BID; postdose blood draws for pharmacokinetic analyses were completed after the morning 200‐mg dose, and no further doses were administered.