Figure 6.

Monitoring changes in vasculature due to PDT using PA imaging. Validation of pre‐ and post‐HPPH‐PDT changes in vasculature of basal cell carcinoma‐harboring mice with PA imaging, taken before PDT administration (A), 1 min post‐PDT (B) and 10 min post‐PDT (C). Vascular area was reduced by 49% and 90%, and blood vessel diameter was reduced 23% and 63%, respectively. Scale bar = 500 μm. (D) Example of StO₂ decrease and return to near‐endogenous levels during verteporfin‐based PDT in the mouse ear blood vessel. Adapted with permission from 66 and 71.