Table 2.
Rosuvastatin Pharmacokinetic Parameters
| Fasted | ||
|---|---|---|
| Parameter | Rosuvastatin 10 mg (n = 12) | Rosuvastatin 10 mg Plus AZD5718 200‐mg Tablet (m = 12) |
| AUC0‐∞, ng·h/mL | ||
| Arithmetic mean (SD) | 45.30 (21.87)a | 56.91 (30.41)b |
| Geometric mean (%CV) | 41.00 (50.3)a | 50.47 (54.9)b |
| AUC0‐last, ng·h/mL | ||
| Arithmetic mean (SD) | 54.19 (36.22) | 49.39 (28.28) |
| Geometric mean (%CV) | 45.26 (67.6) | 43.46 (54.7) |
| Cmax, ng/mL | ||
| Arithmetic mean (SD) | 5.560 (3.773) | 6.738 (4.219) |
| Geometric mean (%CV) | 4.590 (72.1) | 5.743 (62.9) |
| tmax, h | ||
| Median (range) | 5.00 (0.50‐6.00) | 2.00 (2.00‐5.00) |
| t½λz, h | ||
| Arithmetic mean (SD) | 16.0 (6.09)a | 16.4 (5.72)b |
| Geometric mean (%CV) | 14.7 (39.6)a | 16.5 (29.5)b |
AUC0‐∞, area under the plasma concentration‐time curve from time 0 to infinity; AUC0‐last, area under the plasma concentration‐time curve from time 0 to time of last quantifiable concentration; Cmax, maximum observed plasma concentration; CV, coefficient of variation; SD, standard deviation; tmax, time to reach maximum observed plasma concentration; t½λz, plasma half‐life associated with terminal slope of a semilogarithmic concentration‐time curve.
a
n = 9.
b
n = 10.