Table 1.

SAR of substituents at N-1 of the imidazole ring.

Compound	R	FPA Kd(μM)*	Compound	R	FPA Kd (μM)*
2a		1.0 ±0.3	2i		0.4 ±0.1
2b		3.2 ±0.5	2j		11 ±3
2c		4.0 ±0.7	2k		2.1 ±0.7
2d		5.2 ±0.9	2l		4.5 ±0.8
2e		1.2 ±0.2	2m		3.4 ±0.7
2f		5.5 ±0.7	2n		8 ± 2
2g		4.0 ±0.6	2o		38 ±3
2h		0.4 ±0.1	2p		>40

^*Data displayed is the average of at least 3 independent replicates ± standard deviation.