Table 1.
Numbers and characteristics of patients diagnosed with an AIDS‐defining malignancy (ADM), viral non‐AIDS defining malignancy (NADM) or a nonviral NADM, by calendar period of diagnosis
| Characteristics at start of ART and at diagnosis of cancer | Cancer diagnosis 1996–2005 | Cancer diagnosis 2006–2015 | ||||
|---|---|---|---|---|---|---|
| ADM (n = 1,091) | NADM viral (n = 186) | NADM nonviral (n = 424) | ADM (n = 1,071) | NADM viral (n = 441) | NADM nonviral (n = 996) | |
| Age, years: median (IQR) | ||||||
| ART start | 38 (32, 47) | 39 (34, 47) | 43 (36, 53) | 39 (32, 47) | 41 (34, 48) | 46 (38, 54) |
| Diagnosis of cancer | 40 (34, 48) | 43 (36, 50) | 45 (39, 56) | 42 (36, 50) | 46 (40, 53) | 51 (44, 60) |
| CD4 cells/mm3, median (IQR) | ||||||
| ART start | 125 (41, 264) | 183 (68, 320) | 160 (67, 301) | 170 (60, 300) | 201 (98, 322) | 211 (82, 330) |
| Diagnosis of cancer | 170 (64, 320) | 239 (103, 408) | 263 (119, 435) | 238 (96, 416) | 350 (185, 550) | 414 (240, 631) |
| RNA copies/ml log median (IQR) | ||||||
| ART start | 5.1 (4.6, 5.6) | 4.9 (4.2, 5.3) | 5.0 (3.3, 5.5) | 5.1 (4.6, 5.5) | 4.9 (4.2, 5.4) | 5.0 (4.4, 5.4) |
| Diagnosis of cancer | 3.2 (2.3, 5.0) | 2.5 (1.7, 4.1) | 2.3 (1.7, 3.5) | 2.4 (1.7, 4.7) | 1.7 (1.6, 1.8) | 1.7 (1.5, 1.7) |
| Sex and transmission risk group, n (%) | ||||||
| MSM | 549 (50%) | 78 (42%) | 140 (33%) | 554 (52%) | 225 (51%) | 369 (37%) |
| Male PWID | 68 (6%) | 36 (19%) | 60 (14%) | 51 (5%) | 54 (12%) | 107 (11%) |
| Female PWID | 34 (3%) | 4 (2%) | 17 (4%) | 28 (3%) | 9 (2%) | 38 (3%) |
| Male heterosexual | 184 (17%) | 46 (25%) | 95 (22%) | 186 (17%) | 82 (19%) | 257 (26%) |
| Female heterosexual | 144 (13%) | 13 (7%) | 67 (16%) | 173 (16%) | 40 (9%) | 159 (16%) |
| Male other/unknown | 88 (8%) | 9 (5%) | 41 (10%) | 60 (6%) | 24 (5%) | 48 (5%) |
| Female other/unknown | 24 (2%) | 0 (0%) | 4 (1%) | 19 (2%) | 7 (2%) | 18 (2%) |
| AIDS at ART start | ||||||
| No | 526 (48%) | 140 (75%) | 281 (66%) | 644 (60%) | 329 (75%) | 715 (72%) |
| Yes | 565 (52%) | 46 (25%) | 143 (34%) | 427 (40%) | 112 (25%) | 281 (28%) |
| Hepatitis C virus at ART start | ||||||
| Negative | 866 (79%) | 126 (68%) | 290 (68%) | 859 (80%) | 318 (72%) | 739 (74%) |
| Positive | 93 (9%) | 41 (22%) | 74 (17%) | 91 (9%) | 87 (20%) | 141 (14%) |
| Missing/unknown | 132 (12%) | 19 (10%) | 60 (14%) | 121 (11%) | 36 (8%) | 116 (12%) |
| Ever smoked | ||||||
| No | 215 (20%) | 28 (15%) | 36 (8%) | 340 (32%) | 105 (24%) | 218 (22%) |
| Yes | 209 (19%) | 58 (31%) | 120 (28%) | 335 (31%) | 193 (44%) | 469 (47%) |
| Missing/unknown | 667 (61%) | 100 (54%) | 268 (63%) | 396 (37%) | 143 (32%) | 309 (31%) |
Abbreviations: ART, antiretroviral therapy; MSM, men who have sex with men; PWID, people who inject drugs.