Figure 3.

Clustered similarity heatmap of H3K4me1 and H3K27ac enhancers in hMSC and differentiated chondrocytes vs Roadmap cell types. The Jaccard similarity coefficient was calculated between state 13_EnhS in the Transwell chondrogenesis model and 9_EnhA1 in Roadmap 18 state model across cell types. Both states are characterized by high enrichment of H3K4me1 and H3K27ac. Stem cells and differentiated chondrocytes from this study are labeled “hMSC” and “CHON”, respectively. Chondrocytes are indicated by black boxes. A list of Roadmap cell types and their ID codes can be found on the Roadmap project website (http://www.roadmapepigenomics.org)