Fig. 8.

Left: visualization of the parameter space Θ of the VAFs. Orange: somatic variants agree with (θ_h,θ_c)∈{0}×(0,1], which means that no healthy cells have the variant (θ_h=0), while some cancer clones do have the variant (θ_c>0). Germline variants (blue) are described by ${\theta }_h\in \{\frac{1}{2},1\}$ and absent variants (red dot) by θ_h=0,θ_c=0. Subclonal somatic variants in the healthy (normal) tissue are described by θ_h∈(0,0.5). Right: diagram of the model presented in the “The model” section (white circles, latent variables; gray circles, observable variables). Each column corresponds to one alignment ($Z_i^h$ or $Z_j^t$) with its hyperparameters ${\xi }_i^h,{\omega }_i^h$ or ${\xi }_j^t,{\omega }_j^t$. Due to (potential) sample impurity (denoted by α in the text), θ_h has an influence on the alignments $Z_j^t$ from the tumor sample