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. 2020 Apr 28;39:73. doi: 10.1186/s13046-020-01579-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — CPI-613 inhibits lipid metabolism through suppressing ACC activity in pancreatic cancer cells. a, b The effects of CPI-613 on lipid metabolism and glycolysis. AsPC-1 and PANC-1 cells were treated with or without 200 μM CPI-613 for 48 h, followed by Western blot with Glycolysis antibody sampler kit (a) and Fatty acid and lipid metabolism antibody sampler kit (b), respectively. c, d The effects of CPI-613 on the accumulation of lipid droplets determined by Oil-Red-O staining. The representative images and quantitative data from three independent experiments were shown in (c) and (d), respectively. e The effects of CPI-613 on released FAA levels evaluated by Free Fatty Acid Quantification Kit. **p < 0.01