Table 2.
Comparison of the best models, prediction accuracies, cross-validation consistencies, and P values for END identified by generalized multifactor dimensionality reduction analysis
| Best modela | Training balanced accuracy | Testing balanced accuracy | Cross-validation consistency | Sign test (P value) |
|---|---|---|---|---|
| 16 | 0.613 | 0.582 | 7/10 | 6 (0.432) |
| 1,2 | 0.418 | 0.534 | 8/10 | 8 (0.296) |
| 1, 2, 3 | 0.612 | 0.623 | 10/10 | 9 (0.019) |
| 1, 2, 3, 4 | 0.513 | 0.586 | 8/10 | 6 (0.632) |
| 1, 2, 3, 4, 5 | 0.617 | 0.522 | 9/10 | 8 (0.763) |
| 1, 2, 3, 4, 5, 6 | 0.543 | 0.514 | 7/10 | 7 (0.604) |
| 1, 2, 3, 4, 5, 6, 7 | 0.476 | 0.495 | 6/10 | 5 (0.835) |
| 1, 2, 3, 4, 5, 6, 7, 8 | 0.543 | 0.566 | 7/10 | 7 (0.351) |
| 1, 2, 3, 4, 5, 6, 7, 8, 9 | 0.446 | 0.552 | 8/10 | 5 (0.675) |
| 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 | 0.612 | 0.624 | 6/10 | 6 (0.723) |
| 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,11 | 0.575 | 0.513 | 7/10 | 7 (0.372) |
| 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,11,12 | 0.484 | 0.497 | 5/10 | 6 (0.667) |
| 1, 2,3, 4, 5, 6, 7, 8, 9, 10,11,12,13 | 0.597 | 0.583 | 7/10 | 5 (0.432) |
| 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,11,12,13,14 | 0.582 | 0.605 | 8/10 | 6 (0.317) |
| 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,11,12,13,14,15 | 0.622 | 0.572 | 6/10 | 8 (0.186) |
| 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,11,12,13,14,15,16 | 0.475 | 0.402 | 4/10 | 5 (0.726) |
END early neurological deterioration
a Numbers 1–16 represent rs4244285, rs2317676, rs16863323, rs17110453, rs11871251, rs776746, rs1371097, rs701265, rs1439010, rs2242480, rs9859538, rs4986893, rs1934980, rs1799853, rs1057910, and rs2032562, respectively