Fig. 5.

Functional metagenomic comparison of the gut microbiome in different mouse groups reveals that B. animalis may mediate a protective effect against influenza by the specific metabolic pathways. a Distribution of all KO terms enriched in the GX.SG group compared with the GX.DG or NC group. The yellow color indicates the KO terms related to neither B. animalis nor B. pseudolongum; the green color indicates the KO terms related to B. animalis but not to B. pseudolongum; the red color indicates the KO terms related to B. pseudolongum but not to B. animalis; the blue color indicates the KO terms related to both B. animalis and B. pseudolongum. b Functional composition of the KO terms enriched on day 2 post-infection in the GX.SG group compared with both the GX.DG and NC groups and contributions of B. animalis or B. pseudolongum to these functions. Only the KO terms labeled with a module (M) number are shown