TABLE 3.
Predicted stability values for wild-type and mutated molecules
| Molecule and substitution | ΔG | ΔΔG |
|---|---|---|
| TAF1-TAF7 | −58.66 | |
| TAF1 p.Gly680Asp-TAF7 | −55.49 | −3.17 |
| TAF1 p.Arg727Pro-TAF7 | −60.22 | 1.56 |
| TAF1 p.Phe873Val-TAF7 | −56.97 | −1.69 |
| TAF1 p.Arg890Cys-TAF7 | −58.44 | −0.22 |
| TAF1 p.Ser985Phe-TAF7 | −48.65 | −10.01 |
| TAF1 double bromodomain | −28.51 | |
| TAF1 double bromodomain p.Arg1397Gln | −27.67 | −0.84 |
| TAF1 double bromodomain p.Asn1481Ile | −24.38 | −4.13 |
| TAF1 double bromodomain p.Asn1481Ser | −27.32 | −1.19 |
| TAF1 double bromodomain p.His1485Arg | −28.23 | −0.28 |
| TAF1 double bromodomain p.Ala1527Val | −28.21 | −0.30 |
| TAF1 double bromodomain p.Lys1576Glu | −27.47 | −0.04 |
Abbreviations: TAF1, TATA-box binding protein associated factor 1.