Table 1.
Genetic distances |
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MHC | Region | Length | V | C | Si | %Si | No. differences | All sites | ABS | Non-ABS |
Class I | Exon 2 | 249 | 36 | 213 | 21 | 8.43 | 17.07 ± 2.71 | 0.07 ± 0.01 | 0.19 ± 0.05 | 0.04 ± 0.01 |
Exon 3 | 263 | 40 | 223 | 13 | 4.94 | 16.73 ± 2.42 | 0.07 ± 0.01 | 0.18 ± 0.05 | 0.05 ± 0.01 | |
Intron 2 | 200/202 | 12 | 190 | 3 | 1.48 | 4.80 ± 1.41 | 0.03 ± 0.01 | — | — | |
Alpha 1 | 83 | 22 | 61 | 13 | 15.66 | 10.67 ± 1.95 | 0.14 ± 0.03 | 0.40 ± 0.11 | 0.08 ± 0.03 | |
Alpha 2 | 87 | 17 | 70 | 4 | 4.60 | 7.60 ± 1.79 | 0.09 ± 0.02 | 0.33 ± 0.12 | 0.05 ± 0.02 | |
Class II-DRB | Exon 2 | 243/246 | 41 | 205 | 6 | 2.44 | 22.17 ± 3.20 | 0.10 ± 0.02 | 0.20 ± 0.04 | 0.06 ± 0.01 |
Beta 1 | 81/82 | 25 | 57 | 5 | 6.10 | 14.33 ± 2.43 | 0.20 ± 0.04 | 0.50 ± 0.13 | 0.10 ± 0.03 |
NOTE.—V, variable; C, conserved; Si, parsimony-informative sites; %Si, Si percentage. The mean number (± standard error) of differing nucleotides and amino acids among the MHC I and MHC II-DRB alleles, respectively, are shown. Genetic distances are presented for all sites, ABS and non-ABS.