TABLE 1.
Bacterial burdens (means ± SD) in standard and iron-overloaded murine thigh infection models averaged across all strains studied
| Treatment and parametera | Values (log10 CFU/thigh) for each model |
P value | |
|---|---|---|---|
| Standard model | Iron overloaded | ||
| Meropenem 24-h efficacy (12 strains) | |||
| Baseline | 5.77 ± 0.45 | 5.92 ± 0.47 | 0.064 |
| Saline (Δ) | +2.94 ± 0.99 | +2.90 ± 0.77 | 0.833 |
| Meropenem HSR (Δ) | −0.81 ± 1.94 | −1.19 ± 2.04 | 0.247 |
| Cefiderocol 24-h efficacy (31 strains) | |||
| Baseline | 5.75 ± 0.47 | 5.81 ± 0.51 | 0.227 |
| Saline (Δ) | +3.17 ± 1.07 | +3.43 ± 0.77 | 0.008 |
| Cefiderocol HSR (Δ) | −1.46 ± 1.40 | −1.55 ± 1.48 | 0.536 |
| Cefiderocol 72-h efficacy (15 strains) | |||
| Baseline | 5.52 ± 0.44 | 5.54 ± 0.38 | 0.697 |
| Saline 24 h (Δ) | +3.54 ± 0.77 | +3.53 ± 0.71 | 0.905 |
| Cefiderocol HSR 24h (Δ) | −1.77 ± 1.12 | −1.95 ± 0.77 | 0.187 |
| Saline 48 h (Δ) | +3.13 ± 1.15 | +3.88 ± 0.47 | <0.001 |
| Cefiderocol HSR 48 h (Δ) | −2.05 ± 1.82 | −2.35 ± 1.12 | 0.179 |
| Saline 72 h (Δ) | +2.02 ± 1.83 | +3.73 ± 0.16 | 0.037 |
| Cefiderocol HSR 72 h (Δ) | −2.48 ± 1.48 | −2.53 ± 1.42 | 0.807 |
a
Burdens in saline-dosed controls and treatment groups are presented as changes from baseline. Δ, change in bacterial density relative to baseline. HSR, human-simulated regimen.