TABLE 2.

Frequencies of selecting P. aeruginosa single-step mutants with decreased susceptibility to LpxC inhibitors

Strain	Compound	Frequenciesa at:
		2× MIC	4× MIC	8× MIC	16× MIC
K767	2	2.16 × 10–8	3.6 × 10–10	<1.79 × 10–10	<1.79 × 10–10
K767	3	7.27 × 10–8	3.16 × 10–9	3.51 × 10–10	<7 × 10–10
PAO1V	2	1.98 × 10–7	1 × 10–8	4.77 × 10–10	<9.55 × 10–10
PAO1V	3	3.77 × 10–7	2.28 × 10–8	<1.14 × 10–9	<1.14 × 10–9
PAO1V	4	TNTC	3.97 × 10–10	7.93 × 10–11	ND
K2153	4	TNTC	1.13 × 10–7	3.31 × 10–9	ND

^aTNTC, too numerous to count; ND, not determined.