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Impact of fabG mutation and efflux pumps on susceptibility to LpxC inhibitor compounds in P. aeruginosa
| Strain | Relevant factor | MIC (μg/ml)a
|
|||
|---|---|---|---|---|---|
| CHIR-090 | Compound 4 | Compound 3 | Compound 2 | ||
| K767 | Wild type | 1 | 0.25 | 0.25 | 0.25 |
| K767-CDR0061 | fabG mutation | 8 | 2 | 2 | 1 |
| K1454 | MexAB-OprM up | 8 | 2 | 2 | 2 |
| K767-CDA0033 | MexCD-OprJ up | 16 | 0.25 | 4 | 0.5 |
| K2153 | Wild type | 2 | 0.5 | 1 | 0.5 |
| K2376 | MexEF-OprN up | 16 | 8 | 4 | 4 |
| K2153-CDR0063 | MexEF-OprN up | >16 | 16 | 16 | >4 |
Susceptibility shifts ≥ 4-fold are indicated in boldface.
