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Impact of LpxCG208S on susceptibility of P. aeruginosa PAO1 to CHIR-090 and on LpxC enzymatic activity and binding to CHIR-090
| Strain | CHIR-090 MIC (μg/ml) | Protein | kcat (s−1) | Km (μM) | kcat/Km (s−1 M−1) | Mean Ki app (nM) ± SD (CHIR-090) |
|---|---|---|---|---|---|---|
| K767 | 0.5 | LpxC | 0.89 | 5.89 | 1.51 x 105 | 0.13 ± 0.01 |
| K767-LpxCG208S | 2 | LpxCG208S | 0.53 | 32.4 | 1.64 x 104 | 9.64 ± 2.08 |
