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Impact of LpxC overexpression and LpxCA214V amino acid substitution on susceptibility to compound 1 and CHIR-090 in PAO1 strain K767
| Strain | MIC (μg/ml) |
|
|---|---|---|
| Compound 1 | CHIR-090 | |
| K767 | 1 | 1 |
| K767 (pAK1900) | 1 | 1 |
| K767 (pAK-LpxC WT) | 4 | 4 |
| K767 (pAK-LpxCA214V) | 16–32 | 2 |
| K767 (pAK-LpxC WT UP) | 32 | 64 |
| K767 (pAK-LpxCA214V UP) | >128 | 32 |
