TABLE 3.
Parameter (unit) | Value |
|||||
---|---|---|---|---|---|---|
Ceftolozane |
Shrink rate (%) |
Tazobactam |
Shrink rate (%) |
|||
Mean | SD | Mean | SD | |||
CLCVVHDF (liters/h) | 2.659 | 0.783 | 0.00 | 2.973 | 0.603 | 0.06 |
CLresidual (liters/h) | 0.596 | 0.504 | 0.00 | 3.254 | 0.867 | 0.011 |
Vpost (liters) | 17.578 | 10.871 | 0.00 | 19.685 | 14.382 | 0.010 |
Vpre (liters) | 25.184 | 7.499 | 0.00 | 28.206 | 6.603 | 0.126 |
K12 (h−1) | 0.43 | 0.718 | 0.00 | 0.561 | 0.638 | 0.092 |
K21 (h−1) | 0.676 | 0.908 | 0.00 | 1.01 | 1.01 | 0.013 |
Kd (h−1) | 1.596 | 0.495 | 0.00 | 1.584 | 0.483 | 0.013 |
Veffluent (liters) | 2.178 | 0.801 | 0.00 | 2.609 | 1.561 | 0.006 |
Qpre (liters/h) | 0.834 | 1.863 | 0.00 | 2.547 | 2.455 | 0.009 |
Qpost (liters/h) | 2.42 | 1.451 | 0.00 | 3.612 | 1.204 | 0.005 |
Vperipheral (liters) | 73.379 | 39.042 | 0.00 | 77.196 | 32.267 | 0.011 |
SD, standard deviation; CLCVVHDF, clearance by continuous venovenous hemodiafiltration; CLresidual, residual non-CVVHDF clearance; Vpost, volume of the postfilter compartment; Vpre, volume of the prefilter compartment; K12, rate constant for transfer from the prefilter compartment to the postfilter compartment; K21, rate constant for transfer from the postfilter compartment to the prefilter compartment; Kd, rate constant for transfer out of the effluent compartment (“drainage”); Veffluent, volume of the effluent compartment; Qpre, intercompartmental clearance between the prefilter and the peripheral compartments; Qpost, intercompartmental clearance between the postfilter and peripheral compartments; Vperipheral, volume of the peripheral compartment.