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. 2019 Dec 20;64(1):e01655-19. doi: 10.1128/AAC.01655-19

TABLE 3.

Parameter estimates for the final ceftolozane and tazobactam modelsa

Parameter (unit) Value
Ceftolozane
Shrink
rate (%)
Tazobactam
Shrink
rate (%)
Mean SD Mean SD
CLCVVHDF (liters/h) 2.659 0.783 0.00 2.973 0.603 0.06
CLresidual (liters/h) 0.596 0.504 0.00 3.254 0.867 0.011
Vpost (liters) 17.578 10.871 0.00 19.685 14.382 0.010
Vpre (liters) 25.184 7.499 0.00 28.206 6.603 0.126
K12 (h−1) 0.43 0.718 0.00 0.561 0.638 0.092
K21 (h−1) 0.676 0.908 0.00 1.01 1.01 0.013
Kd (h−1) 1.596 0.495 0.00 1.584 0.483 0.013
Veffluent (liters) 2.178 0.801 0.00 2.609 1.561 0.006
Qpre (liters/h) 0.834 1.863 0.00 2.547 2.455 0.009
Qpost (liters/h) 2.42 1.451 0.00 3.612 1.204 0.005
Vperipheral (liters) 73.379 39.042 0.00 77.196 32.267 0.011
a

SD, standard deviation; CLCVVHDF, clearance by continuous venovenous hemodiafiltration; CLresidual, residual non-CVVHDF clearance; Vpost, volume of the postfilter compartment; Vpre, volume of the prefilter compartment; K12, rate constant for transfer from the prefilter compartment to the postfilter compartment; K21, rate constant for transfer from the postfilter compartment to the prefilter compartment; Kd, rate constant for transfer out of the effluent compartment (“drainage”); Veffluent, volume of the effluent compartment; Qpre, intercompartmental clearance between the prefilter and the peripheral compartments; Qpost, intercompartmental clearance between the postfilter and peripheral compartments; Vperipheral, volume of the peripheral compartment.