TABLE 4.

Cumulative fractional response against Pseudomonas aeruginosa EUCAST MIC distribution for exposure during the first 24 h of treatment^a

Dosing regimen	CFR rate by PK/PD target for empirical therapy			CFR rate by PK/PD target for directed therapy
	40 %fT>MIC	60 %fT>MIC	100 %fT>MIC	40 %fT>MIC	60 %fT>MIC	100 %fT>MIC
0.375 g q8h	0.82	0.79	0.65	0.99	0.96	0.80
0.375 g 4 h EI q8h	0.82	0.79	0.24	0.99	0.96	0.29
0.375 g LD + 1.125 g continuous infusion	0.83	0.83	0.68	1.00	1.00	0.83
0.75 g q8h	0.86	0.84	0.77	1.00	1.00	0.94
0.75 g 4 h EI q8h	0.86	0.86	0.51	1.00	1.00	0.62
0.75 g LD + 2.25 g continuous infusion	0.86	0.86	0.79	1.00	1.00	0.96
1.5 g q8h	0.87	0.87	0.85	1.00	1.00	1.00
1.5 g 4 h EI q8h	0.87	0.87	0.69	1.00	1.00	0.84
1.5 g LD + 4.5 g continuous infusion	0.87	0.87	0.86	1.00	1.00	1.00
1.5 g LD for 24 h + 0.75 g q8h	0.87	0.87	0.85	1.00	1.00	1.00
3.0 g q8h	0.90	0.88	0.86	1.00	1.00	1.00
3.0 g 4 h EI q8h	0.90	0.88	0.79	1.00	1.00	0.96
3.0 g LD + 9.0 g continuous infusion	0.92	0.91	0.87	1.00	1.00	1.00
3.0 g LD + 0.75 g q8h	0.87	0.87	0.86	1.00	1.00	1.00

^aPK, pharmacokinetic; PD, pharmacodynamic; CFR, cumulative fractional response; EI, extended infusion; q8h, every 8 h intermittent infusion (1 h); % fT_>MIC, percentage of time free drug concentration was above the MIC; LD, loading dose over 1 h; continuous infusion, continuous infusion over 24 h.