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Results of ex vivo interaction study between cefiderocol and plasma from deferoxamine-treated mice
| Model | Cefiderocol concn (mg/liter) | Measured cefiderocol concn (mg/liter) by day after deferoxamine cessation |
||
|---|---|---|---|---|
| 1 | 3 | 7 | ||
| Standard | 50 | 47.2 ± 4.0 | 49.7 ± 1.1 | 49.1 ± 1.5 |
| Iron depletion | 50 | 49.4 ± 1.5 | 49.3 ± 1.4 | 51.2 ± 4.1 |
| Standard | 5 | 4.9 ± 0.3 | 5.3 ± 0.1 | 5.2 ± 0.2 |
| Iron depletion | 5 | 5.1 ± 0.4 | 5.1 ± 0.6 | 5.4 ± 0.8 |
