FIG 1.

Courses of HEV RNA in blood serum and stool, HEV variants detected in serum, and ALT levels before and during ribavirin treatment in an immunosuppressed patient. Amino acids are displayed in green for the wild type and in red for resistance-associated variants and are given in ratios for next-generation sequencing (NGS) results. The percentage refers to the mutation. HEV RNA, hepatitis E virus RNA (continued line, lower limit of detection 250 IU/ml in serum; dots, lower limit of detection 250 IU/ml in stool); RBV, ribavirin; ALT, alanine transaminase; dashed line, upper limit of normal of alanine transaminase.