. 2019 Dec 20;64(1):e01344-19. doi: 10.1128/AAC.01344-19

TABLE 2.

Amino acid changes of PBPs in MRSA strains that showed high MIC values (>32 μg/ml) to quinazolinones

Strain	spa	MLST	CC	MIC for β-lactams^a (μg/ml)	Compound with MIC >32 μg/ml	Location of amino acid substitutions for:
Strain	spa	MLST	CC	MIC for β-lactams^a (μg/ml)	Compound with MIC >32 μg/ml	PBP 1	PBP 2	PBP 2a	PBP 3	PBP 4
C1657	t127	ST1	CC1	CPT, 0.5; BPR, 1; TZP, >256; MEM, >32	Q2	V617M	None	G246E	H556L	T189S
C5287	t008	ST8	CC8	CPT, 0.5; BPR, 1; TZP, >256; MEM, >32	Q1	None	R30K	None	None	None
K399	t051	ST247	CC247	CPT, 1; BPR, 2; TZP, >256; MEM, >32	Q1, Q2, Q5	None	None	G246E	None	None
C2878	t1451	ST398	CC398	CPT, 1; BPR, 1; TZP, >256; MEM, 6	Q1, Q2, Q5	F465L, D480E, D662N, S664T	D270E, T439V, D489E, T691A	S225R	None	E398A

TZP, piperacillin-tazobactam; MEM, meropenem; CPT, ceftaroline; BPR, ceftobiprole.