TABLE 1.
MIC distribution of 16 M. mycetomatis isolates against 9 antifungal agents
| Antifungal agent | MIC90 (μg/ml) for: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| All isolates |
Pyomelanin |
Non-pyomelanin |
||||||||
| Visual | Vizion | Spectrophotometric |
Visual | Spectrophotometric |
Visual | Spectrophotometric |
||||
| 570 nm | 620 nm | 570 nm | 620 nm | 570 nm | 620 nm | |||||
| Itraconazole | 0.12 | 0.06 | 0.5 | 0.12 | 0.12 | 0.06 | 0.12 | 0.12 | 0.12 | 0.12 |
| Voriconazole | 0.12 | 0.12 | 0.5 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 | 0.25 |
| Posaconazole | 0.12 | 0.12 | 0.25 | 0.25 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 |
| Fluconazole | 16 | 8 | 64 | 16 | 16 | 16 | 16 | 8 | 32 | 8 |
| Amphotericin B | 1 | 1 | 2 | 1 | 1 | 0.5 | 0.5 | 1 | 0.5 | 1 |
| 5-Flucytosine | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 | >64 |
| Caspofungin | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 |
| Micafungin | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 |
| Anidalufungin | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 | >8 |