TABLE 4.
Activity of antibiotics against MRSA, MSSA, and VRE over 96 h in a hollow-fiber infection model
| Study | Mean log10 CFU/ml ± SD |
|||||
|---|---|---|---|---|---|---|
| MRSA ATCC 33591 |
MSSA ATCC 29213 |
VRE ATCC 700802 |
||||
| 96 h | Change from 0 h |
96 h | Change from 0 h |
96 h | Change from 0 h |
|
| Growth control | 10.79 ± 0.03 | +0.85 ± 0.02 | 11.05 ± 0.03 | +1.96 ± 0.11 | 10.70 ± 0.02 | +0.95 ± 0.01 |
| ADEP4 | 10.85 ± 0.07 | +0.42 ± 0.09 | 10.98 ± 0.05 | +1.22 ± 0.21 | 10.62 ± 0.04 | +0.67 ± 0.04 |
| LZD | 10.27 ± 0.23 | −0.49 ± 0.16 | NDb | ND | 9.30 ± 0.05 | −0.75 ± 0.02 |
| ADEP4 + LZD | 5.52 ± 0.17 | −4.56 ± 0.23 | ND | ND | 3.65 ± 0.01 | −6.13 ± 0.07 |
| OXA | ND | ND | 10.05 ± 0.09 | −0.04 ± 0.13 | ND | ND |
| ADEP4 + OXA | ND | ND | 2.32 ± 0.62a | −8.06 ± 0.70a | ND | ND |
| AMP | ND | ND | ND | ND | 9.20 ± 0.16 | −0.85 ± 0.23 |
| ADEP4 + AMP | ND | ND | ND | ND | 1.00 ± 0.00a | −8.80 ± 0.05a |
| LZD + AMP | ND | ND | ND | ND | 9.03 ± 0.03 | −1.07 ± 0.03 |
a
The limit of detection was 10 CFU/ml.
b
ND, not determined.