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Mean (±SD) plasma CRS3123 concentration-time profiles on day 1 following dose 1 (A) and day 10 following dose 19 (B) and mean (±SD) plasma CRS3123 trough concentrations for the three cohorts (C). Trough concentrations samples were acquired immediately prior to doses 3 (day 2), 7 (day 4), 11 (day 6), 15 (day 8), and 19 (day 10).
