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. 2020 Mar 12;7(4):406–419. doi: 10.1002/acn3.51004

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© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Boxplots illustrating the log1p abundances of Butyricicoccus, Clostridium cluster XVIII, Methanobrevibacter, Parabacteroides, Clostridium cluster IV, Gemmiger, and Sporobacter genera within the population. Abundances were log1p‐transformed for graphic purposes. Individual data points (dots) may overlap. HC, healthy controls (N = 120, including FGFP samples). PPMS, primary progressive multiple sclerosis (N = 26). BMS, benign multiple sclerosis (N = 20). RRMS_U, untreated active RRMS (N = 24). RRMS_I, interferon‐beta‐treated RRMS (N = 24). RRMS_R, RRMS during relapse (N = 4). Kruskal–Wallis test (N = 218, Pcorr < 0.1) with post hoc Dunn tests.