Table 4.

Compositional differences between all MS patients and HC. Only significant results are shown. Reported P‐values after Wilcoxon rank‐sum test, with Benjamini–Hochberg corrected P‐values (Wilcoxon rank‐sum test, N = 218, Pcorr < 0.1).

Genus	N	Effect size	Median MS	Median HC	P	Pcorr
Alistipes	218	−0.18	5.24	4.72	0.007	0.056
Anaerotruncus	218	−0.16	0.69	0	0.016	0.080
Butyricicoccus	218	−0.24	1.7	2.3	<0.001	0.007
Clostridium cluster IV	218	−0.35	4.14	3.18	<0.001	<0.001
Faecalicoccus	218	−0.16	0	0	0.017	0.080
Gemmiger	218	−0.30	2.71	3.73	<0.001	<0.001
Intestinibacter	218	−0.21	0.69	1.79	0.002	0.029
Lactobacillus	218	−0.18	0.69	0	0.009	0.065
Methanobrevibacter	218	−0.20	1.61	0	0.004	0.037
Olsenella	218	−0.19	0.69	0	0.006	0.049
Parabacteroides	218	−0.15	4.56	4.12	0.022	0.097
Roseburia	218	−0.17	6.36	6.71	0.014	0.078
Ruminococcus	218	−0.17	4.86	4.52	0.014	0.078
Sporobacter	218	−0.39	1.61	0.69	<0.001	<0.001

HC, healthy controls (N = 120, including FGFP samples); MS, multiple sclerosis (N = 98); Effect size (Z/sqrt(N)); Median MS, median abundance of genus (log1p transformed) for MS patients; Median HC, median abundances of genus (log1p transformed) for HC; P, uncorrected P‐value; Pcorr, P‐value corrected for multiple comparisons with Benjamini–Hochberg, FDR.